About Case Western Reserve University. Case Western Reserve University in Cleveland, OH reports an overall acceptance rate of 35.3%, an early-round acceptance rate of 25.0%, an SAT middle 50% of 1450–1530, a class size of 1,619, and a yield of 15.0% based on the most recent Common Data Set filings. Elite private research university in Cleveland. Top-ranked biomedical engineering, nursing, and medical programs adjacent to University Hospitals and Cleveland Clinic.